CASE REPORT article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1588300
Adult-Onset S�ll's Disease during pregnancy: two case reports and a comprehensive literature review
Provisionally accepted
- Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
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Background: Adult-onset Still’s disease (AOSD) is a rare systemic inflammatorydisorder marked by recurrent fever, rash, arthritis, and multi-organ involvement. Its occurrence with pregnancy complicates diagnosis and management.Objective: To present the diagnosis and treatment process of two pregnant patients with newly diagnosed AOSD.Cases: Two cases of AOSD were initially diagnosed during pregnancy. Case one involved a pregnant woman at 16+2 weeks of gestation with recurrent fevers, rash, and myalgia. She responded well to treatment with methylprednisolone and cyclosporine and subsequently had a normal vaginal delivery. Case two involved a pregnant woman at 30+6 weeks of gestation who presented with systemic joint pain and fever. After being diagnosed with AOSD, she underwent a cesarean section. Treatment included methylprednisolone, cyclosporine, and addition of methotrexate postpartum. Conclusions: AOSD can be triggered by pregnancy, requiring a multidisciplinary approach for optimal management and fetal outcomes.
Keywords: pregnancy outcomes, Adult-onset Still's disease, AOSD, Safe medication use, inflammatorydisorder
Received: 05 Mar 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Xu, Huang, Li, Li, Lu, Yang, Zhang, Li and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenchao Xu, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
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