GENERAL COMMENTARY article
Front. Med.
Sec. Dermatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1590092
This article is part of the Research TopicExploring Pigmentary Disorders: Pathogenesis to TreatmentView all 3 articles
Commentary: Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model
Provisionally accepted
- Peking Union Medical College Hospital (CAMS), Beijing, China
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The recent article by Hu et al. has challenged the existing hypothesis regarding the potential 11 pathogenic role of sympathetic nerves in vitiligo. Their study randomized mice into two groups: a 12 chemical sympathectomy group, which underwent sympathetic denervation via 6-hydroxydopamine 13 (6-OHDA), and an untreated control group. Both groups were subsequently induced with vitiligo 14 using the melanoma-regulatory T cell (Treg)-induced vitiligo model. Epidermal melanocytes and 15 CD8 + T cells of tail skin were quantified before and after induction. The authors discovered that 16 tyrosine hydroxylase (TH) + sympathetic nerve fibers in both back and tail skin were significantly 17 depleted by 6-OHDA treatment, whereas the numbers of tail epidermal melanocytes and CD8 + T 18 cells were comparable between the two groups, before and after vitiligo induction.
Keywords: skin disease1, vitiligo2, sympathetic nerve3, commentary4, mouse model5. 9
Received: 08 Mar 2025; Accepted: 11 Jul 2025.
Copyright: © 2025 Wang and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tao Wang, Peking Union Medical College Hospital (CAMS), Beijing, China
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