CASE REPORT article
Front. Med.
Sec. Pathology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1590907
This article is part of the Research TopicBiomarker Discovery and Therapeutic Innovations in Genito-Urinary Cancer ManagementView all 14 articles
Case report: The first account of primary myeloid sarcoma of the testis combined with ipsilateral epididymal epithelioid hemangioendothelioma
Provisionally accepted
Xi Chen
Li Liu*- Department of Pathology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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This case report describes a 35-year-old male with primary myeloid sarcoma (MS) of the testis and concurrent ipsilateral epididymal epithelioid hemangioendothelioma (EHE)-an exceptionally rare combination. Myeloid sarcoma typically involves the skin and bone, but testicular involvement is rare, particularly as an isolated tumor without hematologic malignancy. This makes diagnosis challenging.Epithelioid hemangioendothelioma is a rare vascular tumor, typically found in the liver, lungs, and bones, and epididymal EHE is scarcely reported.The patient had a left testicular nodule for 6 months and experienced pain for 2 days. Ultrasound and MRI revealed abnormalities in the left testis and epididymis. Histopathological examination of the epididymal biopsy showed tumor cells with specific morphological features, and immunohistochemistry (IHC) indicated CD31(+), CD34(+), Fli-1 (+), ERG(+), Ki-67 (+5%+), along with WWTR1-CAMTA1 gene fusion by fluorescence in situ hybridization (FISH), confirming EHE. Subsequently, testicular resection was performed, and the testicular tumor cells were diffusely arranged.
Keywords: myeloid sarcoma, Testis tumors, Epithelioid hemangioendothelioma, epididymis tumors, Immunohistochemistry, WWTR1-CAMTA1 gene
Received: 10 Mar 2025; Accepted: 26 Aug 2025.
Copyright: © 2025 Chen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li Liu, Department of Pathology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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