CASE REPORT article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1591462
Case Report: From Kaposi's sarcoma to Primary Effusive Lymphoma
Provisionally accepted
- 1Guizhou Medical University, Guiyang, China
- 2Department of Dermatology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China
- 3Department of Endoscopy, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China
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Primary effusion lymphoma (PEL) is a rare B-cell lymphoma with an extremely poor prognosis that is associated with long-term persistent latent infection with Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). However, studies on the correlation between KSHV genotype and PEL development in elderly patients are still lacking. We present the first global case of non-HIV, non-effusive, difficult-to-diagnose PEL with disseminated Kaposi's sarcoma (KS) in an elderly patient of Bouyei nationality, dynamically demonstrating that KSHV and EBV co-infection promote tumorigenesis. Phylogenetic analysis based on the Open Coding Framework (ORF)-K1 gene indicated that five samples from the patient's blood (mtl A), saliva (mtl B), descending colon (mtl C), skin (mtl D), and gastric mucosa (mtl E) may belong to a new subtype, Cnew. KSHV genotypes appear to show a pattern of traceability consistent with the human Y-chromosome DNA haplogroup tree.
Keywords: Human herpesvirus 81, lymphoma2, Kaposi's sarcoma3, Epstein-Barr Virus Infections4, Ethnicity5
Received: 16 Mar 2025; Accepted: 30 Jul 2025.
Copyright: © 2025 Wang, Xia, Deng, Xu and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanping Jiang, Guizhou Medical University, Guiyang, China
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