CASE REPORT article
Front. Med.
Sec. Pathology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1591783
This article is part of the Research TopicUrothelial Neoplasms: An Integrated Approach to Prevention, Diagnostics, and Personalized TherapyView all 7 articles
Endoscopic Submucosal Dissection Revealed Isolated Gastric Metastasis from Primary Bladder Urothelial Carcinoma: Clinicopathological Analysis and Literature Review
Provisionally accepted
- 1Zibo Central Hospital, Shandong, China
- 2Zibo Zhoucun District People's Hospital, Zibo, China
- 3Qilu Hospital, Shandong University, Jinan, China
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A 73-year-old male was admitted to our department with complaints of upper abdominal distension, accompanied by dull pain and belching for more than 10 days. Gastroscopy revealed a broad-based raised lesion, approximately 1.0 cm in diameter, on the anterior wall of the gastric body, with a central star-shaped depression, erosion, and surrounding congestion. Endoscopic ultrasonography showed a lesion on the lower anterior wall of the gastric body involving the submucosal layer, with a subsequent biopsy indicating cancer. Notably, the patient had undergone cystectomy seven months earlier, with a pathological diagnosis of an invasive high-grade nested variant of urothelial carcinoma staging pT2N0Mx. An endoscopic submucosal dissection (ESD) was eventually conducted for diagnostic purposes. A gross examination of the specimen revealed a superficial elevated tumor measuring 1.2 × 1 × 0.3 cm, with a central depression, a grey-white cut surface, and firm texture. Microscopically, the tumor cells exhibited architectural and cytomorphological features resembling those of a bladder tumor. Immunohistochemical staining was positive for GATA-3, 34βE12, CK7 and negative for p63, which were consistent with those observed in bladder tumors. Based on the clinicopathological features and medical history, a diagnosis of gastric oligometastatic urothelial carcinoma was made. Following ESD, the patient received four cycles of gemcitabine chemotherapy and showed no sign of recurrence at the 41-month follow-up.
Keywords: urothelium carcinoma, Gastric metastases, Oligometastasis, Treatment, Endoscopic Submucosal Dissection
Received: 11 Mar 2025; Accepted: 22 Jul 2025.
Copyright: © 2025 Xu, Li, Qiu, Yu, Yin, Xu and Jian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fabao Xu, Qilu Hospital, Shandong University, Jinan, China
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