ORIGINAL RESEARCH article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1591791
Age-Stratified Association Between Serum Uric Acid and Lumbar Bone Mineral Density in Elderly Chinese Women with Vertebral Compression Fractures: A Cross-Sectional Analysis
Provisionally accepted
- The First People’s Hospital of Huzhou, Huzhou, China
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Objective: To investigate the association between serum uric acid (SUA) levels and lumbar bone mineral density (BMD) in elderly Chinese women with vertebral compression fractures (VCFs), with a specific focus on age-dependent variations in this association. Methods: We conducted a cross-sectional study of 490 female patients aged ≥60 years with VCFs. SUA levels served as the primary exposure variable, and lumbar spine BMD was the outcome variable. Multivariate linear regression models were employed to adjust for potential confounders, incorporating comprehensive subgroup analyses. Results: A statistically significant positive and independent correlation emerged between SUA levels and spine lumbar BMD after multivariable adjustment (β = 0.045, 95 % CI 0.026-0.064). The association demonstrated pronounced variability across age groups, with a more robust correlation in patients younger than 75 years (β = 0.069, 95 % CI 0.039-0.098) compared to those 75 years and older (β = 0.026, 95 % CI 0.002-0.050), revealing a statistically significant interaction (P = 0.008). Conclusion: Our findings reveal a nuanced, age-dependent positive correlation between SUA levels and lumbar BMD in elderly Chinese women with vertebral compression fractures. These results suggest SUA may serve as a potential biomarker for fracture risk assessment and bone health evaluation, particularly in younger elderly populations.
Keywords: Serum uric acid, bone mineral density, Vertebral compression fractures, Elderly women, Age stratification
Received: 28 Mar 2025; Accepted: 26 Aug 2025.
Copyright: © 2025 Zhu, Xia, Min, Hu, Li and Mei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chao Mei, The First People’s Hospital of Huzhou, Huzhou, China
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