ORIGINAL RESEARCH article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1593007
Biological Characteristics of SARS-CoV-2 Resistant Populations by Integrated Gut Microbiota Sequencing, Metabolomics and Proteomics: A Cohort Comparison Study
Provisionally accepted
- 1School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong Province, China
- 2Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, China
- 3The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China
- 4Department of Pulmonary and Critical Care Medicine, Zhuhai Hospital of Integrated Traditional Chinese & Western Medicine, Zhuhai, China
- 5Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China
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Objective: Most research reports on COVID-19 infections have focused on the correlation between the severity of the disease symptoms and immune deficits, while the mechanisms affecting the susceptibility to SARS-CoV-2 remain largely unknown. The study aimed to comprehensively analyze the differences in immunity, gut microbiota, metabolism, and proteomics between the SARS-CoV-2 resistant population and susceptible population. Methods and Results: In this cohort comparison study, participants were rigorously selected based on inclusion and exclusion criteria in a continuous enrollment manner through continuous enrollment using combined questionnaires and clinical data, ultimately including 25 SARS-CoV-2 resistant volunteers versus 16 SARS-CoV-2 infected patients.The clinical information of the participants was recorded in detail, and fecal and blood samples were collected in a standardized manner for subsequent multi omics analysis, including gut microbiota sequencing, metabolomics, and proteomics. This study has preliminarily elucidated the characteristics of the gut microbiota, serum metabolites, and serum proteins in the SARS-CoV-2 resistant population. It exhibits a unique metabolic signature characterized by elevated levels of serum phosphatidylinositol and the abundance of Prevotella, which may serve as a potential predictive biomarker for resistance to SARS-CoV-2. Conclusion: Given the crucial role of phosphatidylinositol in cell membrane architecture and viral infectivity, this study provides a promising entry point for further research into the pathogenesis and prevention strategies of COVID-19.
Keywords: SARS-CoV-2, COVID-19, Resistant population, multiomics, Phosphatidylinositols, Gut Microbiota, Metabolomics, Proteomics
Received: 13 Mar 2025; Accepted: 30 May 2025.
Copyright: © 2025 Xu, Li, Xu, CHEN, Deng, Chen and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoyin Chen, School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong Province, China
Yinji Xu, The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, 510170, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.