SYSTEMATIC REVIEW article
Front. Med.
Sec. Precision Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1593985
Biomaterial-Driven Regenerative Drug Delivery: A Vicennial Bibliometric Landscape
Provisionally accepted
- 1Chengdu Integrated TCM and Western Medical Hospital, Chengdu, Sichuan Province, China
- 2Department of Oncology, Liuzhou People's Hospital, Liuzhou, Guangxi Zhuang Region, China
- 3Department of Pharmacy, Chongzhou People's Hospital, Chongzhou, China
- 4University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
- 5Surgery Ward I, Yizhou District TCM Hospital, Guangxi, China
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Biomaterials are at the forefront of advancing drug delivery systems and regenerative medicine, playing a pivotal role in shaping the future of therapeutic approaches. The rising burden of chronic diseases and the growing need for effective tissue repair have accelerated the development of these interdisciplinary fields. However, a comprehensive overview of the trajectory of biomaterials research, key players, and the shifting research landscape in drug delivery and regenerative medicine remains limited. To fill this gap, an analysis was conducted on articles and reviews published in the Science Citation Index Expanded of Web of Science Core Collection between January 2005 and December 2024. The findings present a bibliometric visualization that highlights key trends in publication volume, geographical distribution of research, leading institutions, top journals, research categories, and emerging keywords. The biomaterials field has seen considerable expansion, particularly in the postpandemic COVID-19 period, although research output remains uneven across regions. The United States continues to lead in both academic influence and commercialization, while China follows closely in terms of publication quantity and the contribution of high-impact institutions. The convergence of drug delivery, regenerative medicine, and biomaterials has fostered innovative interdisciplinary research, with a strong focus on integrating biomaterials with advanced stem cell therapies, tissue engineering, and precision drug delivery systems. Moreover, intelligent technologies are paving the way for promising research frontiers, encompassing personalized medicine, precision healthcare, organoid and organ-on-a-chip developments, as well as digital cell modeling. Despite the promising potential of these innovations, challenges related to scalability, safety, and regulatory approval remain significant. The analysis also addresses the future directions of these fields and explores strategies for overcoming existing barriers to advance these emerging technologies.
Keywords: Regenerative Medicine, Drug delivery, Biomaterials, Biblio metrics, Tissue engeneering
Received: 19 Mar 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Shen, Deng, Jing, Wang, Liu and Mo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xin Shen, Chengdu Integrated TCM and Western Medical Hospital, Chengdu, 610041, Sichuan Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.