ORIGINAL RESEARCH article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1597371
Clinical characteristics and prognosis of non-typhoidal Salmonella bacteremia in children versus adults: A retrospective study
Provisionally accepted
- Dongguan Tungwah Hospital, Dongguan, China
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Background: Several studies have reported the clinical characteristics of non-typhoidal Salmonella (NTS) bacteremia in children or adults. However, there is a scarcity of data that directly compares the clinical characteristics and prognosis in children versus adults.Methods: A retrospective study was conducted on bloodstream infections caused by NTS in hospitalized patients from January 1, 2018, to December 31, 2024. The clinical and relevant laboratory data of patients between adult and pediatric groups were compared，and the risk factors predicting the duration of antibiotic treatment were analyzed by multivariate logistic regression..In total, 52 patients with NTS bloodstream infection met eligibility criteria, 28(53.8%) were children versus adults 24(46.2%). Among the concomitant diseases, respiratory infection account for the main proportion(child 78.6% vs adult 50.0%, P=0.031). More than half of pediatric patients isolated NTS from their stool (child 57.1% vs adult 20.8% ， P=0.008). The duration of antibiotic treatment in children is significantly lower than that in the adult group{child 8(6.5,10.5) vs adult 15(7.25,21.25)， P=0.002}, but the mortality rate was no significantly different.Multivariate logistic regression analysis showed that child (OR=0.209，95% CI：0.058~0.751， P=0.016) was tend to a shorter course of antibiotic treatmentA shorter course of antibiotic treatment was observed in pediatric patients, however, due to its biases and limitations, further prospective randomized controlled trials are needed to generalize our findings.
Keywords: Non-typhoidal Salmonella, Bacteremia, Clinical Characteristics, haematological parameters, Child
Received: 21 Mar 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Su, zhong, liang and wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: yanhong wang, Dongguan Tungwah Hospital, Dongguan, China
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