ORIGINAL RESEARCH article
Front. Med.
Sec. Translational Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1597404
This article is part of the Research TopicEnhancing Sports Injury Management through Medical-Engineering InnovationsView all 14 articles
Clinical Study on Basal Blood Perfusion in the Major Arteries of the Limbs
Provisionally accepted
- 1First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China
- 2Hebei North University, Zhangjiakou, Hebei Province, China
- 3Shulan Hangzhou Hospital, Hangzhou, Zhejiang Province, China
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Investigation of Basal Limb Artery Perfusion to Guide Ex Vivo Perfusion Flow Rates for Replantation Methods: Eligible volunteers (n=304, 146M/158F, age 41.68±11.28) undergoing exams at PLAGH Fourth Medical Center (Feb-Dec 2024) were recruited. Basal blood perfusion (diameter, velocity, volume) in brachial, ulnar, radial, popliteal, dorsalis pedis, and posterior tibial arteries was measured using portable Doppler ultrasound. Mean hemodynamic parameters were calculated. Multiple linear regression analyzed relationships between BMI, body surface area (BSA), and arterial perfusion volume. Interaction tests assessed sex and "three-high" status (hypertension, hyperglycemia, hyperlipidemia) as potential modifiers of the BMI/BSA-perfusion relationship. Interaction terms BSA×BMI and age×diabetes status were included based on significance and pathophysiology. Results: Mean upper limb perfusion: brachial 74.9±22.5 ml/min, ulnar 35.7±12.6 ml/min, radial 36.8±13.5 ml/min (ulnar vs radial NS, p>0.05). Lower limb: popliteal 114.1±34.2 ml/min, dorsalis pedis 53.3±18.1 ml/min, posterior tibial 59.2±21.0 ml/min (posterior tibial > dorsalis pedis, p<0.001). Regression showed BMI negatively associated and BSA positively associated with limb perfusion volume; together they formed a linear predictive model. A significant interaction effect existed between BMI and BSA on limb flow (p<0.05). Diabetes status interaction was non-significant (p>0.05). Conclusion: Quantitative limb perfusion parameters and their correlations with BMI/BSA enable hemodynamic customization for ex vivo perfusion systems in limb replantation. This approach balances metabolic support and ischemia-reperfusion risk mitigation during preservation, advancing personalized protocols.
Keywords: Color Doppler ultrasound, Arteries, Limb replantation, Hemodynamic parameters, Perfusion
Received: 21 Mar 2025; Accepted: 17 Jul 2025.
Copyright: © 2025 Zhang, Wang, Shi, Gao, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianzheng Zhang, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China
Jianhui Li, Shulan Hangzhou Hospital, Hangzhou, Zhejiang Province, China
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