CASE REPORT article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1598144
When neuroglial tissue wanders: a unique case of subpleural heterotopia in a triploid foetus and review of the literature
Provisionally accepted
Viktor Procházka1,2
Valeria Skopelidou1,3
Patricie Delongová1,3*
Pavel Hurník1,3
Richard Špaček1
David Matura1
Jan Pavlíček1,3Andrea Gřegořová1Jana Vaculová1,3Jozef Škarda1,3- 1University Hospital Ostrava, Ostrava, Czechia
- 2University Hospital in Motol, Prague, Prague, Czechia
- 3University of Ostrava, Ostrava, Czechia
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Heterotopic occurrence of neuroglial tissue is an exceedingly rare phenomenon with unclear pathogenesis, often presenting as lesions outside the central nervous system (CNS). We report a unique case of heterotopic neuroglial tissue identified in the thoracic cavity of a foetus aborted at 14 weeks due to a suspected Dandy-Walker malformation. The foetus exhibited neuroglial tissue growth subpleurally, alongside a suspected Dandy-Walker malformation and ventricular septal defect. While theories such as vascular embolization, aspiration, and aberrant migration attempt to explain such occurrences, the exact aetiology remains elusive. Our case suggests a potential association between triploidy and neuroglial heterotopia, supporting the aberrant migration and differentiation theory.
Keywords: Brain heterotopia, Neural tube defect, Neuroglial heterotopia, Dandy-Walker malformation, Triploidy
Received: 22 Mar 2025; Accepted: 09 Sep 2025.
Copyright: © 2025 Procházka, Skopelidou, Delongová, Hurník, Špaček, Matura, Pavlíček, Gřegořová, Vaculová and Škarda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Patricie Delongová, patricie.delongova@fno.cz
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