ORIGINAL RESEARCH article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1598234
Efficacy of budesonide suspension in the treatment of lobar pneumonia by fiberoptic bronchoscopic alveolar lavage
Provisionally accepted
- Binzhou Medical University Hospital, Binzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective: To probe the efficacy of budesonide suspension in treating lobar pneumonia by fiberoptic bronchoscopic alveolar lavage. Methods: A total of 176 preschool and school-age children with lobar pneumonia in the pediatric respiratory department of Binzhou Medical University Hospital from December 2020 to December 2021 were selected and divided into observation group (OG, n=88) and control group (CG, n=88) based on the wishes of their families. Children in both groups were given azithromycin sequential treatment. The CG was given fiberoptic bronchoscope alveolar lavage with sodium chloride injection, and the OG was treated with fiberoptic bronchoscope alveolar lavage with sodium chloride injection + inhalation of budesonide suspension. The treatment, inflammatory factor levels, immune function, lung function indicators, adverse reactions and clinical efficacy were compared between both groups. Results: The total effective rate of the OG was 90.91%, which was better than 81.82% of the CG (χ 2 =3.095, P<0.05). After treatment, the serum IL-6, CRP and ESR levels declined, and IL-2 level was elevated in the OG relative to the CG (P<0.05). The levels of IgM, IgA, IgG, FVC, FEV1, PEF, FEF25, FEF50, FEF75 and FEF25-75 in the OG were enhanced compared to the CG (P<0.05). The antipyrexia time, the disappearance time of lung shadow, the improvement time of cough and expectoration, and the disappearance time of lung rales in the OG were shorter compared to the CG (P<0.05). Conclusion: Budesonide combined with fiberoptic bronchoscopy lavage in treating lobar pneumonia in children with Mycoplasma pneumoniae is effective in enhancing the therapeutic effect, relieving the clinical symptoms and signs of children faster, significantly reducing the inflammatory response, and significantly improving lung function. It is safe, effective and has no adverse reactions.
Keywords: Budesonide, Lobar pneumonia, Fiberoptic bronchoscopy, alveolar lavage, Immune function
Received: 22 Mar 2025; Accepted: 26 May 2025.
Copyright: © 2025 Ji, Fu, Zhang, Chen, Xing, Ji, Zhou and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiangqin Song, Binzhou Medical University Hospital, Binzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.