ORIGINAL RESEARCH article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1598624
Diagnostic Value of the Combined Detection of Serum Tumour Necrosis Factor-α and Faecal Calprotectin in Early Sepsis-related Encephalopathy
Provisionally accepted
- Jiangxi Provincial People's Hospital, Nanchang, China
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Objective: To investigate the value of tumour necrosis factor-α (TNF-α) and faecal calprotectin in the early diagnosis and prognosis of sepsis-associated encephalopathy (SAE).We recruited 150 patients with sepsis, admitted from January 2020 to January 2022. Of these, 80 patients had SAE and 70 patients did not. The levels of serum TNF-a and faecal calprotectin of patients while in the intensive care unit were measured and correlated with the acute physiology and chronic health evaluation scoring system II (APACHE II) score, the sequential organ failure assessment (SOFA) score and 28-day mortality. We examined the value of TNF-α and faecal calprotectin in the diagnosis and prognosis of SAE.The APACHE Ⅱ and SOFA scores and 28-day mortality of the SAE group were significantly higher than those of the sepsis group, which indicated that the condition of the SAE group was more critical. In the SAE group, TNF-α and faecal calprotectin levels were positively correlated with the APACHE II and SOFA scores (P < 0.05), which may be related to disease severity. Assessing TNF- level alongside faecal calprotectin level is highly valuable for the diagnosis of SAE and determining poor prognoses in SAE patients.Conclusions: TNF-α and faecal calprotectin may be involved in the pathogenesis of SAE.Both have high specificity and sensitivity for early SAE diagnosis. Moreover, they have good predictive value and can serve as prognostic indicators.
Keywords: Serum Tumour Necrosis Factor-α, Faecal calprotectin, Early Sepsis-related Encephalopathy, diagnostic value, pathogenesis of SAE
Received: 23 Mar 2025; Accepted: 12 May 2025.
Copyright: © 2025 Chen, Ouyang, Yang, Wu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhenhuan Chen, Jiangxi Provincial People's Hospital, Nanchang, China
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