MINI REVIEW article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1598798
Medical Gases in Respiratory Diseases: Ozone, Argon, and Nitric Oxide as Game-Changers in Therapeutics
Provisionally accepted
- 1The First Hospital of Putian City, Putian, China
- 2Nankai University, Tianjin, China
- 3University of Science and Technology of China, Hefei, Anhui Province, China
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Respiratory diseases pose a significant global health burden, prompting the exploration of novel therapeutic strategies. This narrative review consolidates existing knowledge and critically examines the evolving role of medical gases, ozone, argon, and nitric oxide (NO), in respiratory medicine. Based on recent literature, it highlights how these gases, originally used for their physicochemical properties, have now undergone a "functional crossover," revealing their broad therapeutic potential.Analysis of available evidence indicates Ozone exhibits dual mechanisms: redox balance regulation and antimicrobial effects, demonstrating efficacy in COVID-19 pneumonia and hospital disinfection. Argon, when delivered through cold atmospheric plasma jets (CAPPJ), provides broad-spectrum antibacterial effects and targeted treatment for bronchopleural fistulas. NO, beyond its vasodilatory role, is now a dynamic tool for airway inflammation monitoring and precision asthma management. However, challenges persist, including optimizing therapeutic windows, standardizing treatment protocols, and assessing long-term safety and efficacy. Future directions emphasize precision medicine, incorporating biomarkers, AI-driven diagnostics, and combination therapies to overcome current challenges and unlock the full potential of medical gases in treating respiratory diseases.
Keywords: Respiratory Tract Diseases, Ozone, Argon, Nitric Oxide, COVID-19
Received: 25 Mar 2025; Accepted: 22 May 2025.
Copyright: © 2025 Chen, Cai and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lizhen Chen, The First Hospital of Putian City, Putian, China
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