CLINICAL TRIAL article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1600630
Effect of magnesium sulfate different routes combined with quadratus lumborum block on postoperative analgesia and recovery quality of patients undergoing laparoscopic total hysterectomy:A prospective randomized, controlled trial
Provisionally accepted
- 1Zigong First People's Hospital, Zigong, China
- 2Department of Anesthesiology, Ya 'an People Hospital, Ya 'an, China
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ABSTRACT：Objective To investigate the effects of different ways of magnesium sulfate injection combined with ultrasound-guided quadratus lumborum block (QLB) on postoperative analgesia and recovery quality of patients undergoing laparoscopic total hysterectomy under general anesthesia.Method A total of 88 patients who underwent laparoscopic hysterectomy in Ya'an people's Hospital from June , 2020 to February , 2022, aged from 18 to 65, were randomly divided into three groups: control group (group A, n=29), local magnesium sulfate group (group B, n=29) and intravenous magnesium sulfate group (Group C, n=30) All patients were treated with general anesthesia and patient controlled intravenous analgesia (PCIA) after surgery. General information, visual analogue scale (VAS) at 2h, 6h, 12h, 24h, 48h after surgery, dosage of sufentanil in 24h after surgery, the duration of QLB analgesia (time of first pressing analgesic pump after surgery), 40-item quality of recovery score (QoR-40) before the surgery and on the 3d after surgery, hypotension, bradycardia, postoperative nausea and vomiting(PONV) at 1-3d after surgery, postoperative delirium (POD), skin pruritus, chills, lower limb movement block and other adverse reactions were observed and recorded.Result Compared with group A, VAS score and postoperative sufentanil consumption were decreased in group B and group C, and the onset time of first postoperative analgesia request was prolonged(P < 0.05), while there was no statistically significant difference between group B and group C (P > 0.05).The QoR-40 score of group B and group C on 3d after surgery was higher than that of group A (P < 0.05), while there was no statistically significant difference between group B and group C (P > 0.05).The incidence of PONV in group B and group C was lower than that of group A, and the difference was statistically significant (P < 0.05), while there was no statistically significant difference between group B and group C (P > 0.05). No hypotension, bradycardia, POD, pruritus, chills, lower limb movement block were observed.Conclusion Intravenous or local use of magnesium sulfate combined with QLB has similar postoperative analgesic effect and promoting postoperative recovery effect in patients undergoing laparoscopic hysterectomy.
Keywords: Quadratus lumborum block, Magnesium sulphate, Uterine surgery, Postoperative pain, Quality of recovery Trial registration:ChiCTR2200055978,date of registration:01/30/2022
Received: 29 Mar 2025; Accepted: 18 Jul 2025.
Copyright: © 2025 Wang, Zhang, Zhou and Ran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuzhi Zhou, Department of Anesthesiology, Ya 'an People Hospital, Ya 'an, China
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