BRIEF RESEARCH REPORT article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1601169
This article is part of the Research TopicTherapies Approaches in Venous Thromboembolism Management and CoagulationView all 9 articles
Correlation between decreased PaCO2 and thrombus site and 90d prognosis in patients with acute pulmonary embolism Running Head: Correlation between decreased PaCO2 and thrombus site
Provisionally accepted
yang danrong
Liu Yi*- Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China
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Objective: This study aimed to investigate the correlation between decreased partial pressure of arterial carbon dioxide (PaCO₂) and thrombus location, as well as its association with 90-day prognosis in patients with acute pulmonary embolism (PE). Method: A retrospective analysis was conducted on the risk factors, clinical characteristics, and diagnostic findings of PE patients presenting with decreased PaCO₂ at our hospital. Results: Multivariate logistic regression analysis revealed that decreased PaCO₂ in PE was significantly associated with thrombosis in the right pulmonary artery, thrombosis in the left lower lobe pulmonary arteries, and pulmonary hypertension (PH). Pearson correlation analysis showed a weak negative correlation between decreased PaCO₂ and PASP and PVOI. Spearman correlation analysis indicated a weak negative correlation between decreased PaCO₂ and computed tomography severity (CTS)defined risk PE. Kaplan-Meier survival analysis demonstrated that decreased PaCO₂ was not associated with 90-day mortality (χ² = 0.263, P = 0.608). Conclusion: A significant proportion of PE patients presented with decreased PaCO₂, which was correlated with thrombosis in the right pulmonary artery and left lower lobe pulmonary arteries. However, decreased PaCO₂ was not associated with 90-day mortality in PE patients.
Keywords: Pulmonary Embolism, PaCO2, prognosis, Relevant factors, D-dimer；
Received: 27 Mar 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 danrong and Yi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liu Yi, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China
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