ORIGINAL RESEARCH article
Front. Med.
Sec. Gene and Cell Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1601806
Trends and Emerging Frontiers of Mesenchymal Stem Cells in Intervertebral Disc Degeneration: A Bibliometric Analysis (2000–2024)
Provisionally accepted
- 1Second Affiliated Hospital of Inner Mongolia Medical University, Hohehot, China
- 2The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
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Background: Intervertebral disc degeneration (IVDD) is a major global cause of disability, and mesenchymal stem cell (MSC) therapy offers a promising regenerative solution by targeting the root causes of degeneration, unlike conventional symptom-focused treatments. This bibliometric analysis explores trends and emerging research areas in MSC applications for IVDD.Methods: A comprehensive literature search was conducted in the Web of Science Core Collection database, covering publications from 2000 to 2024. Bibliometric and visualized analysis was performed using VOSviewers, CiteSpace and the R package "Bibliometrix".Results: This bibliometric analysis reviewed 931 articles, revealing an overall upward trend in publication activity. Leading authors included Sakai Daisuke, Grad Sibylle, and Alini Mauro. China and the USA led in publication volume and citation counts, while the United Kingdom achieved the highest average citations per publication. The University of Pennsylvania and Zhejiang University were the most productive institutions. Key journals included Biomaterials, Spine, and Tissue Engineering Part A. Earlier core keywords primarily focused on foundational concepts such as "gene expression", "articular cartilage", "anulus fibrosus" and "extracellular matrix". Recent keyword bursts include "activation", "autophagy", "extracellular vesicles", "apoptosis", "exosome", and "oxidative stress".Conclusions: This bibliometric analysis revealed key research focuses on foundational biological mechanisms, translational applications, and addressing specific challenges in the use of MSC for IVDD. Future research is likely to focus on optimizing MSC functionality, developing cell-free therapies such as extracellular vesicles, and targeting the molecular mechanisms involved in disc degeneration and regeneration.
Keywords: Intervertebral Disc Degeneration, Mesenchymal Stem Cells, Regenerative Medicine, bibliometric analysis, Citespace, VOSviewer
Received: 28 Mar 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Zhao, Li, Cheng, Xu, Bai, Yu, Liu, Yin and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Heping Yin, Second Affiliated Hospital of Inner Mongolia Medical University, Hohehot, China
Yimin Wu, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.