ORIGINAL RESEARCH article
Front. Med.
Sec. Family Medicine and Primary Care
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1601863
This article is part of the Research TopicCardiovascular Anthropometry For Large Scale Population Studies Volume IIView all 5 articles
Association between Overactive Bladder and Lipid Accumulation Products and Visceral Adiposity Index: Results from NHANES 2005-2018
Provisionally accepted
wenhao wang1,2
xiaolin xu2*- 1Anhui University of Science and Technology, Huainan, China
- 2Fengxian District Central Hospital, Shanghai, Shanghai Municipality, China
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Although obesity is a recognized risk factor contributing to the onset and progression of overactive bladder (OAB), the existing evidence linking lipid accumulation products (LAPs) and the visceral adiposity index (VAI) to OAB remains scarce and subject to debate. Hence, this study was conducted to evaluate the associations between VAI, LAP, and the occurrence of OAB.The information utilized in this research was sourced from the National Health and Nutrition Examination Survey (NHANES), spanning the years 2005 to 2018. The majority of the data pertaining to OAB relied on self-administered questionnaires. To assess the relationships between VAI, LAP, and OAB, we employed multivariate logistic regression models, trend analysis, and subgroup evaluations.The study encompassed a total of 70,190 participants, with 22,928 individuals diagnosed with OAB and 5,776 serving as controls. After accounting for potential confounding factors, a statistically significant positive relationship was noted between both the visceral adiposity index (VAI) and the lipid accumulation product (LAP), as well as the occurrence of overactive bladder (OAB). Respectively, individuals in the highest quartiles of LAP and VAI demonstrated a 56% (OR = 1.555, 95% CI: 1.376 to 1.758) and 22% (OR = 1.225, 95% CI: 1.084 to 1.384) increased probability of OAB when compared to those in the lowest quartile. Additional subgroup analyses revealed that the observed associations were particularly evident in participants under the age of 60 and among women.This study's findings suggest that an increase in both the visceral adiposity index (VAI) and lipid accumulation product (LAP) is associated with a greater occurrence of overactive bladder (OAB), hinting at their possible use as predictive indicators for OAB.
Keywords: Overactive bladder (OAB), lipid accumulation products, visceral adiposity index (VAI), NHANES (National Health and Nutrition Examination Survey), Obesity
Received: 28 Mar 2025; Accepted: 25 Jun 2025.
Copyright: © 2025 wang and xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: xiaolin xu, Fengxian District Central Hospital, Shanghai, 201400, Shanghai Municipality, China
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