CASE REPORT article
Front. Med.
Sec. Nuclear Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1602306
Combined 18 F-AlF-NOTA-FAPI-04 and 18 F-Fluorodeoxyglucose PET/CT in patients with eosinophilic gastroenteritis: a case report and literature review
Provisionally accepted
- First Affiliated Hospital, Dalian Medical University, Dalian, China
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Eosinophilic gastroenteritis (EGE) is a rare chronic inflammatory disorder characterized by eosinophilic infiltration in the gastrointestinal tract. We report a 42-year-old previously healthy man who presented with gradually worsening abdominal pain and bloating for nearly one month. Initial laboratory tests showed elevated eosinophil counts, increased immunoglobulin E levels, and raised C-reactive protein. Enhanced CT revealed diffuse edema of the gastric wall, thickening of the gastric and duodenal walls, enlargement of the abdominal lymph nodes, and thickening of the peritoneum, which was suspected to be caused by malignant tumors. However, gastroscopic pathological examination and multiple ascites examinations showed no obvious malignant cells. To investigate the underlying cause, the combined 18F-AlF-NOTA-FAPI-04 (18F-FAPI) positron emission tomography/computed tomography (PET/CT) and 18F-Fluorodeoxyglucose (18F-FDG) PET/CT were performed, the pattern of increased radionuclide uptake in these mentioned lesions differs from that of malignant neoplasms. Then, EGE was confirmed by diagnostic peritoneal biopsy. This case highlights that combined PET/CT imaging with 18F-FAPI and 18F-FDG demonstrates potential utility in diagnosing EGE, particularly in distinguishing inflammatory processes from malignancies.
Keywords: FDG 1, FAPI2, PET/CT3, Eosinophilic gastroenteritis4, Peritoneal5
Received: 29 Mar 2025; Accepted: 14 Aug 2025.
Copyright: © 2025 Chen, Wu and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jing hui Xie, First Affiliated Hospital, Dalian Medical University, Dalian, China
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