ORIGINAL RESEARCH article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1602428
A controlled study of Gd-EOB-DTPA-enhanced MRI compared with enhanced CT in assessing lesion status after TACE for hepatocellular carcinoma
Provisionally accepted
- Qilu Hospital, Shandong University, Jinan, China
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Abstract Objective: This study aims to evaluate the diagnostic capability of Gd-EOB-DTPA-enhanced MRI in assessing lesion status following Transcatheter Arterial Chemoembolization (TACE) for Hepatocel-lular Carcinoma (HCC), in comparison to Contrast-enhanced CT (CECT). Methods: A total of 56 patients with HCC who underwent Gd-EOB-DTPA-enhanced MRI and CECT scans post-TACE were initially enrolled. The ability of both imaging modalities to differentiate be-tween surviving, new, or necrotic lesions was assessed, using digital subtraction angiography (DSA) or interventional diagnostic results as the reference standard. Detection rates were compared using the chi-square test, while sensitivity, specificity, and accuracy were analyzed with McNemar’s test. Results: After applying inclusion and exclusion criteria, 48 patients were eventually included in the analysis. The reference standard identified 14 cases of surviving lesions, 19 of new lesions, and 15 of necrotic lesions. Gd-EOB-DTPA-enhanced MRI demonstrated a sensitivity of 93.9% (31/33), speci-ficity of 100% (15/15), and a Youden index of 0.939, whereas CECT exhibited a sensitivity of 51.5% (17/33), specificity of 60.0% (9/15), and a Youden index of 0.115. Conclusion: The findings indicate that Gd-EOB-DTPA-enhanced MRI possesses superior diagnostic value for evaluating lesion status in HCC post-TACE compared to CECT, as evidenced by significant differences in sensitivity and specificity (P < 0.05). Key words：Hepatocellular Carcinoma；Transcatheter Arterial Chemoembolization；Gd-EOB-DTPA enhanced MRI；Contrast-enhanced CT；Lesion status
Keywords: Hepatocellular Carcinoma, Transcatheter arterial chemoembolization, Gd-EOB-DTPA enhanced MRI, Contrast-enhanced CT, Lesion status
Received: 29 Mar 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Cheng, Peng, Zhou, Wang, Fan, ZUO, Lv and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Weiwei Lv, Qilu Hospital, Shandong University, Jinan, China
Dexin Yu, Qilu Hospital, Shandong University, Jinan, China
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