ORIGINAL RESEARCH article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1603161
Developing a Procedure Mimicking Transvaginal Mesh Implantation in Women in a Modified POP Rat Model
Provisionally accepted
- 1First Affiliated Hospital, Dalian Medical University, Dalian, China
- 2People's Hospital of Nagqu, Nagqu, China
- 3Zhuzhou People's Hospital, Zhuzhou, China
- 4Maternal and Infant Hospital, Yingkou Economic and Technological Development Zone, Yingkou, China
- 5Women and Children's Hospital of Tibet Autonomous Region, Tibet, China
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Introduction This study aims to establish a simple and reproducible transvaginal mesh surgery rat model based on the modified pelvic organ prolapse rat model.Methods A total of 24 ten-week-old female nulliparous Wistar rats were used in this study. The control group consisted of 6 rats with no interventions. The Ovariectomy group included 6 rats that underwent bilateral ovariectomy. The pelvic organ prolapse group comprised 12 rats that underwent cervical pendant modeling two weeks after bilateral ovariectomy. Fourteen days post-modeling, 6 rats from the pelvic organ prolapse group underwent transvaginal mesh surgery. The Rat Pelvic Organ Prolapse Quantification system was used to evaluate the prolapse condition of the rats before and after pelvic organ prolapse modeling, as well as after transvaginal mesh surgery. Vaginal wall tissue was collected to assess biomechanical changes before and after pelvic organ prolapse modeling. Additionally, vaginal wall and sacral ligament tissues were collected to evaluate structural changes and collagen alterations before and after pelvic organ prolapse modeling.Results The pelvic organ prolapse rat model exhibits anatomical prolapse, biomechanical changes, and pathological changes, including collagen fiber rupture and reduced collagen density. In contrast, the transvaginal mesh rat model demonstrates anatomical recovery in prolapsed rats.Conclusions This study successfully modified the pre-existing rat model of pelvicorgan prolapse and effectively mimicked human transvaginal mesh surgery using this model.
Keywords: Pelvic Organ Prolapse, animal model, Biomechanical, Transvaginal mesh, rat
Received: 31 Mar 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Wang, Long, Yan, Li, De and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qiong De, Women and Children's Hospital of Tibet Autonomous Region, Tibet, China
Zhen Xiao, First Affiliated Hospital, Dalian Medical University, Dalian, China
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