ORIGINAL RESEARCH article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1603596
A Retrospective Review of Nine Cases of Atypical Neurosyphilis
Provisionally accepted
- Department of Neurology, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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Background: Neurosyphilis may manifest in a form resembling autoimmune encephalitis, primarily characterized by cognitive impairment, psychiatric disorders, and seizures. Brain magnetic resonance imaging typically reveals unilateral or bilateral lesions in the mesiotemporal lobe and may also identify abnormalities in the inferior frontal lobe, parietal lobe, occipital lobe, and thalamus. Nevertheless, there are very few reports addressing this particular aspect.We conducted a retrospective review of the medical records of inpatients diagnosed with neurosyphilis who presented with cognitive impairment, psychiatric disorders, and seizures. All patients underwent lumbar puncture and cerebrospinal fluid (CSF) examination. A total of nine inpatients were consecutively enrolled from
Keywords: Atypical neurosyphilis, Mimicking, autoimmune encephalitis, Brain magnetic resonance imaging, Mesiotemporal lobe
Received: 31 Mar 2025; Accepted: 12 Jun 2025.
Copyright: © 2025 Miao, Song, Zhang, Ma, Zhang and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuming Huang, Department of Neurology, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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