CASE REPORT article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1604360
This article is part of the Research TopicCase Reports in Intensive Care Medicine 2025View all 11 articles
Dancing with Death at pH 6.8 and Lactate of 29 mmol/L: Extreme Survival in Severe Metformin-Associated Lactic Acidosis -A Case Report
Provisionally accepted
- 1Centre Hospitalier de Gonesse, Gonesse, Île-de-France, France
- 2Université Sorbonne Paris Nord, Villetaneuse, Île-de-France, France
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Word count: 89 Lactic acidosis is a serious metabolic disorder characterized by an accumulation of lactate in the body, which can lead to a severe acid-base imbalance. Metformin-associated lactic acidosis is a rare but life-threatening complication of metformin therapy, particularly in the setting of acute kidney injury or other conditions that impair lactate clearance. In this case report, we present the remarkable survival of a patient who experienced severe metformin-associated lactic acidosis with a blood pH of 6.8 and a lactate level of 29 mmol/L, which are typically considered incompatible with life.
Keywords: Lactic acidosis, Acute Kidney Injury, Metformin-intoxication, Hemodialysis (HD), Extreme survival
Received: 01 Apr 2025; Accepted: 29 Sep 2025.
Copyright: © 2025 KORTLI, AMATHIEU and GHALAYINI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Said KORTLI, kortlisaid@outlook.com
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