CASE REPORT article
Front. Med.
Sec. Hematology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1605819
This article is part of the Research TopicPrecision Medicine and Targeted Therapies in Gastrointestinal and Genitourinary Solid TumorsView all 12 articles
Gastrointestinal Stromal Tumor with Secondary Thrombocytosis: A Case Report of a High-Risk Patient
Provisionally accepted
- 1Lanzhou University, Lanzhou, China
- 2Lanzhou University Second Hospital, Lanzhou, Gansu Province, China
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Gastrointestinal stromal tumor (GIST) with secondary thrombocytosis is a rare clinical case,exhibiting specificity in clinical diagnosis and treatment.We report a case of GIST with secondary thrombocythemia to raise clinicians' attention to this disease.On October 11, 2024, a 58-year-old male patient was admitted to the hospital due to "intermittent right lower abdominal pain with increased bowel movements for more than 1 month".The patient had no prior history of tumors, chronic inflammatory diseases,hematologic disorders or family history of genetic disorders.MRI-enhanced scans of the small intestine highly indicated a lymphoma of intestinal origin. Small bowel endoscopy and pathological biopsy revealed mild chronic inflammation of the intestinal mucosa, with intact villous architecture, no plasmacytosis, granulomas, or vasculitis, and no indication of GIST.Laboratory tests showed platelet count of 909 × 10⁹/L, white blood cell count of 11.86 × 10⁹/L, neutrophil ratio of 75.10%, lymphocyte ratio of 15.30% and hemoglobin 101 g/L.Bone marrow biopsy microscopically showed a normal number of megakaryocytes without abnormal aggregation and no myelofibrosis, suggesting there was no obvious hematologic malignancy and the thrombocytosis may have been secondary.The patient underwent partial resection of the small intestine and resection of mesenteric lesions on October 18, 2024.The intraoperative frozen section suggested a stromal tumor.The postoperative pathological biopsy suggested a GIST and genetic testing showed a mutation in the c-KIT gene (Exon 13).Postoperatively, the patient was treated with oral imatinib mesylate (400 mg/d) as adjunctive therapy. Three months after surgery, imaging showed no recurrence, platelet decreased and returned to normal levels.
Keywords: Gastrointestinal Stromal Tumor, secondary thrombocythemia, c-kit, Exon 13, case report
Received: 08 Apr 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Li, Liu, Guo, Wang, Han and Mao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jie Mao, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu Province, China
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