REVIEW article
Front. Med.
Sec. Gene and Cell Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1606100
This article is part of the Research TopicExploring the Role of Stem Cells in Bone Health and RegenerationView all articles
Categories, applications, and potential of stem cells in bone regeneration: an overview
Provisionally accepted
Mingyang Jiao1
Ting Shuai2
Zhongfang Zhao3Yuwei Wu2Linwei Yu1Jingwen Sun4
Raffaele De Caro5
Veronica Macchi6
Andrea Porzionato7
Elena Stocco5,6,7*
Chanyuan Jin2*- 1Department of Prosthodontics, Peking University Hospital of Stomatology, Beijing, Beijing Municipality, China
- 2The Second Clinical Division of Peking University School and Hospital of Stomatology, Beijing, China
- 3School of Stomatology, Lanzhou University, Lanzhou, Gansu Province, China
- 4School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China
- 5Section of Human Anatomy, Department of Neuroscience, University of Padova, Padua, Italy
- 6Department of Women’s and Children’s Health, University of Padova, Padua, Italy
- 7Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy
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Bone defects affect many individuals globally and can result in significant suffering and impairment, particularly among the elderly population. In addition, current treatment options for critical-size bone defects, such as autologous or allogeneic bone graft transplantation, present significant challenges.Within this clinical scenario the identification of novel and effective approaches for bone regeneration is urgently needed, and options derived from tissue engineering may be particularly appealing. Bone tissue engineering for bone regeneration involves the application of seed cells, growth factors, and biomaterials to create bioactive substitutes for repairing bone defects. In recent decades, advancements in stem cell research and biological biomaterials have led to remarkable breakthroughs in the field of bone regeneration. In particular, various categories of stem cells have been isolated, characterized, and employed in tissue engineering approaches. This review summarizes the applications of the main types of stem cells currently used for bone regeneration through tissue engineering approaches, and it also pays attention to the most appealing materials for it.
Keywords: Stem Cells, bone tissue engineering, Biomaterials, Bone Regeneration, Regenerative Medicine, Osteogenic differentiation
Received: 04 Apr 2025; Accepted: 31 Jul 2025.
Copyright: © 2025 Jiao, Shuai, Zhao, Wu, Yu, Sun, De Caro, Macchi, Porzionato, Stocco and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Elena Stocco, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy
Chanyuan Jin, The Second Clinical Division of Peking University School and Hospital of Stomatology, Beijing, China
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