SYSTEMATIC REVIEW article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1606786
New Trends and Hotspots in Sepsis-Related Protein Post-Translational Modification: A Bibliometric and Visual Analysis
Provisionally accepted
- Department of Intensive Care Medicine, Northern Jiangsu People's Hospital, Yangzhou, China
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Background: Sepsis is a clinical syndrome characterized by high morbidity and mortality rates, posing a severe threat to human health. Its pathophysiology is complex, involving multiple physiological and pathological processes. Protein post-translational modification (PTM) play a pivotal role in the pathophysiology of sepsis by regulating inflammation, immune responses, and organ dysfunction. In recent years, there has been a growing focus on the association between sepsis and PTM; however, a comprehensive and systematic analysis of the current research status and development trends in this field is still lacking. Methods: This study analyzed literature from the Web of Science Core Collection published between 2005 and 2024. CiteSpace, VOSviewer, and Excel facilitated the bibliometric analysis, visualizing publication trends, contributions across countries/regions and institutions, journal distributions, author collaboration networks, and keyword clusters. Results: A total of 1705 articles were included, originating from 58 countries/regions. The annual publication volume showed exponential growth (R²=0.9662), with China leading the way (48.68%), followed by the United States (29.27%). Shanghai Jiao Tong University emerged as a high-yield institution (n=51), while the University of Pittsburgh demonstrated the highest citation impact (with an average of 109.87 citations per article). Prominent journals featuring these articles include Shock (n=77) and the Journal of Immunology (with an average citation of 65.75 times per article). Research hotspots were centered around phosphorylation, ubiquitination, and methylation, with emerging trends such as sepsis-associated acute kidney injury (SA-AKI), autophagy, and mitochondrial dysfunction.Research on the sepsis-related PTM is flourishing. This study systematically reveals the research dynamics and core trends in this field .
Keywords: post-translational modification, Bibliometric, Ubiquitination, Methylation, Sepsis
Received: 06 Apr 2025; Accepted: 26 Jun 2025.
Copyright: © 2025 Zheng, Song, Ma, Jiang, Liu, Wang, Lin and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ruiqiang Zheng, Department of Intensive Care Medicine, Northern Jiangsu People's Hospital, Yangzhou, China
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