Clinical impact of quality nursing combined with health education pathway on quality of life and sleep in severe aplastic anemia patients complicated with infection: A randomized clinical trial

Wei ShenWei Feng^*

• The First Affiliated Hospital of Soochow University, Suzhou, China

Objective: This research aimed to elucidate clinical impact of quality nursing combined with health education pathway on life quality and sleep in severe aplastic anemia (SAA) patients with infection. Methods: A total of 130 SAA patients complicated with infection admitted to the Hematology Department of our hospital from February 2022 to February 2024 were divided into an observation group (OG) and a control group (CG) using a random number table method, with 65 cases each. The CG received conventional nursing. Based on the conventional nursing, OG received quality nursing + health education nursing. The health knowledge awareness rate, quality of sleep, quality of life, inflammatory indicators and immune function indicators, improvement of clinical symptoms and occurrence of adverse reactions received analysis and comparison. Results: After intervention, health knowledge awareness rate in OG depicted elevation in comparison to that in CG (P=0.002); Pittsburgh Sleep Quality Index (PSQI) scores in OG depicted reduction in comparison to those in CG, and sleep time in OG depicted elevation in comparison to that in CG (P<0.0001); The quality of life scores in OG depicted elevation in comparison to those in CG (P<0.0001). The patients’ PSQI scores were inversely proportional to their quality-of-life scores in both groups (P=0.0044, P=0.0007, P=0.0003 and P<0.0001); The patients’ sleep time in both groups was directly proportional to their quality-of-life scores in both groups (P=0.005, P<0.0001, P=0.0005 and P<0.0001). After intervention, C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in OG depicted reduction in comparison to those in CG, and CD4/CD8 ratio in OG depicted elevation in comparison to that in CG (P<0.0001); The time for infection control, time for body temperature to return to normal, time for cough disappearance, and time for lung rales disappearance in OG depicted reduction in comparison to that in CG (P<0.0001); The total incidence of adverse reactions in OG depicted reduction in comparison to that in CG (P=0.013). Conclusion: The combined application of quality nursing and health education pathway in SAA patient care effectively improves health knowledge, sleep, quality of life, immunity, and recovery, and is worth clinical promotion.