CASE REPORT article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1607521
This article is part of the Research TopicDigital Technologies in Hepatology: Diagnosis, Treatment, and Epidemiological InsightsView all 12 articles
Case report: Transjugular intrahepatic portosystemic shunt combined with hemodialysis for refractory ascites treatment in a patient with idiopathic non-cirrhotic portal hypertension and uremia
Provisionally accepted- West China Hospital, Sichuan University, Chengdu, China
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Transjugular intrahepatic portosystemic shunt (TIPS) is a standard treatment for refractory ascites (RA) in patients with cirrhosis. Idiopathic non-cirrhotic portal hypertension (INPH) is a disorder of unknown etiology, clinically characterized by features of portal hypertension. The current therapy is limited to managing portal hypertension and is recommended to be referred to as cirrhosis. Given the elevated risk of overt hepatic encephalopathy (OHE) post-TIPS, TIPS placement is limited in cirrhotic patients with concurrent acute or chronic kidney disease. However, patients with INPH exhibit better liver function and ammonia metabolism than those with liver cirrhosis. The efficacy of TIPS for RA in INCPH patients with uremia on dialysis remains uncertain. We present a case of TIPS placement for RA in a patient with INPH on maintenance hemodialysis for uremia, aiming to explore therapeutic advancements and enhance quality of life in this challenging population.
Keywords: Transjugular intrahepatic portosystemic shunt, Refractory ascites, Idiopathic non-cirrhotic portal hypertension, Uremia, hemodialysis, case report
Received: 07 Apr 2025; Accepted: 19 Jun 2025.
Copyright: © 2025 Wu, Li and Quan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hao Wu, West China Hospital, Sichuan University, Chengdu, China
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