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ORIGINAL RESEARCH article

Front. Med.

Sec. Hematology

Volume 12 - 2025 | doi: 10.3389/fmed.2025.1608870

Comparative assessments of myocardial iron load in thalassemia patients between dark blood and bright blood MRI T2* techniques

Provisionally accepted
Jixing YiJixing Yi1Min WuMin Wu1Suzhen WeiSuzhen Wei1Qiliang HuangQiliang Huang1Bumin LiangBumin Liang2Peng PengPeng Peng3Tao LiTao Li1Fengming XuFengming Xu1*
  • 1Liuzhou Workers Hospital, Liuzhou, China
  • 2Guangxi Medical University, Nanning, Guangxi Zhuang Region, China
  • 3First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi Zhuang Region, China

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Objective: To investigate the difference of black blood (DB) and bright blood (BB) T2* techniques at 1.5T and 3T in the assessment of myocardial iron load in patients with thalassemia (TM) . Methods: As a retrospective study. CMRtools software was used to measure myocardial T2* in 359 patients with moderate(60g/L0.95) were recorded. The difference, correlation and consistency of T2* measured by different methods were compared. Results: There was no significant difference (P > 0.05) in myocardial T2* measured by different methods (1.5T, 3T), and all of them were highly positively correlated (P < 0.05, r s > 0.9). Bland-Altman analysis showed that (1.5T) DB8-T2* and DBx-T2*, DBx-T2* and BBx-T2* had good consistency (P > 0.05). (3T) DB8-T2* and DBx-T2* had good consistency (P > 0.05). There were proportional differences in T2* values measured by the other methods (P < 0.05), and none of them could be considered to have good consistency. Conclusion: DB CMR T2* and BB CMR T2* can be interchangeable in the assessment of myocardial iron load in TM patients. However, DB 3 CMR T2* is more stable and reliable.

Keywords: cardiac magnetic resonance, Dark blood, bright blood, myocardial T2*, Thalassemia

Received: 09 Apr 2025; Accepted: 22 Jul 2025.

Copyright: © 2025 Yi, Wu, Wei, Huang, Liang, Peng, Li and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Fengming Xu, Liuzhou Workers Hospital, Liuzhou, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material