SYSTEMATIC REVIEW article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1609131
Method of invigorating spleen and replenishing kidney and resolving phlegm for Obesity-Type Polycystic Ovary Syndrome: A Network Meta-Analysis and Summary of Herbal Prescription Regularity
Provisionally accepted
- Anhui University of Chinese Medicine, Hefei, China
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Objective: To evaluate the therapeutic efficacy of Invigorating Spleen and Replenishing Kidney and Resolving Phlegm Prescription (ISRKRPP) in treating obesity-type polycystic ovary syndrome (PCOS), and to analyze the prescription regularity through data mining technology. Methods: Databases were retrieved up to September 30, 2024. RCTs on obesity-type PCOS treated with ISRKRPP and Western medicine (WM) were included. The Risk of Bias 2 tool was used for quality assessment. Network meta-analysis was performed using Stata 14.0. After standardizing herb names, build a corresponding herbal database in Excel. Based on Excel and R language, the core drugs and prescription rules used in the treatment of obese PCOS were analyzed and visualized.di Results: A total of 14 articles, involving 1163 patients, 7 prescriptions were included. Network meta-analysis indicated: Qihuang Zengmin Decoction + WM may be optimal for overall efficacy (Confidence in Network Meta-Analysis [CINeMA]: moderate confidence); Cangfu Daotan Decoction + WM showed superiority in reducing BMI (CINeMA: moderate confidence); Method of Regulating and Supplementing Spleen and Kidney + WM most effectively improved HOMA-IR (CINeMA: moderate confidence); Cangfu Daotan Decoction + WM best regulated LH (CINeMA: moderate confidence); Heshi Powder + WM medicine most effectively reduced testosterone (CINeMA: moderate confidence). Herbal Regularity analysis revealed core herbs for the treatment included Rhizoma atractylodis, Poria cocos, Angelica sinensis, Pinellia ternate, and Epimedium. The herbal cluster, including Epimedium, Poria cocos, Angelica sinensis, Citrus, Spina gleditsiae, Salviae miltiorrhizae, Rhizoma atractylodis, Pinellia ternata, Rhizoma cyperi, may be the core prescription for the treatment of obesity-type PCOS. Conclusion: Based on the results of the present studies, ISRKRPP combined with WM can improve the effect of obesity-type PCOS. Due to the limitations of the present studies, more clinical studies are needed for further validation.
Keywords: invigorating spleen and replenishing kidney and resolving phlegm, Obesity-Type Polycystic Ovary Syndrome, Network meta-analysis, Chinese herbs, Prescription regularity
Received: 10 Apr 2025; Accepted: 09 Jul 2025.
Copyright: © 2025 Lyu, Cai and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yueqiao Lyu, Anhui University of Chinese Medicine, Hefei, China
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