CASE REPORT article
Front. Med.
Sec. Nephrology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1609192
This article is part of the Research TopicCase Reports in Critical Care Nephrology 2025/2026View all articles
Glomerular disease associated with cancer : a case series of paraneoplastic nephrotic syndrome
Provisionally accepted
- 1Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China
- 2Department of Nephrology, Jiangxi Medical College, The Second Affiliated Hospital, Nanchang University, Nanchang, China
- 3Department of Minimally Invasive Comprehensive Treatment of Cancer, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China
- 4Department of Nephrology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China
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The association between glomerular diseases and malignancies has been recognized since the 1920s. A diverse spectrum of glomerular lesions can occur in various neoplasms, including both hematologic malignancies and solid tumors. This study presents a case series of paraneoplastic nephrotic syndrome (PNS) associated with three solid tumors: ovarian cancer, pancreatic neuroendocrine tumor (NET) and bladder cancer. The occurrence of PNS is rarely reported in association with these malignancies. Notably, all patients achieved complete or partial remission without receiving corticosteroids or immunosuppressants therapy. These observations accentuate a critical role of malignancy in the pathogenesis of glomerulopathy and underscore the therapeutic primacy of oncological control in these patients.
Keywords: Paraneoplastic glomerular disease, ovarian cancer, Pancreatic neuroendocrine tumor, Bladder cancer, Paraneoplastic nephrotic syndrome
Received: 10 Apr 2025; Accepted: 13 Oct 2025.
Copyright: © 2025 Hu, Ma, Wang, Zhang, Lin, Yang, Lv and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mengsi Hu, drhumengsi@sina.com
Zhimei Lv, zhimeilv@sina.cn
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