REVIEW article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1609296
Effect of modified transhysteroscopic proximal tubal plugging on IVF outcome
Provisionally accepted
- 1Guizhou Medical University, Guiyang, China
- 2Affiliated Baiyun Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China
- 3Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China
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OBJECTIVE: This study aimed to evaluate whether optimizing the placement of microcoil in the fallopian tube during hysteroscopy could enhance IVF-ET pregnancy rates and reduce complications. METHODS: A retrospective cohort study included 94 patients with tubal infertility who underwent tubal embolization at Baiyun Hospital of Guizhou Medical University between May 2019 and December 2023. Patients were divided into two groups: Group A (n=65) used the original technique, while Group B (n=29) used a modified technique. Effective follow-up data were obtained from 42 patients in Group A (Group Aa) and 15 patients in Group B (Group Ba). Key variables, including the mean time to successful IVF pregnancy, number of IVF cycles, clinical pregnancy persistence (gestation ≥12 weeks), and complication rates, were analyzed. RESULTS: The mean time to conception was shorter in Group Ba (6.10 months, median = 7.5 months) compared to Group Aa (11.58 months, median = 12 months), though not statistically significant (p = 0.092). Similarly, the mean number of IVF cycles required for implantation was slightly lower in Group Ba (1.60) than in Group Aa (1.92), with no significant difference (p = 0.236). However, clinical pregnancy persistence rates were significantly higher in Group Ba (10/14, 71.43%) compared to Group Aa (12/32, 37.50%) (χ² = 4.493, p = 0.034). Additionally, Group Aa reported two cases of post-IVF ectopic pregnancy (2/32), while no such cases were observed in Group Ba. CONCLUSION: Optimizing the proximal tubal plugging site via hysteroscopy may enhance clinical pregnancy persistence post-IVF-ET. Further studies are needed to explore the relationship between coil positioning depth and ectopic pregnancy risk, as well as to determine the optimal timing for postoperative IVF-ET. Ongoing pregnancy rates differed markedly by occlusion site: unilateral isthmic occlusion (0%) vs. bilateral (44.44%, P=0.059), suggesting a clinical trend. Conversely, interstitial occlusion yielded high and comparable rates (unilateral: 83.33% vs. bilateral: 62.50%, P=0.393), unaffected by laterality.
Keywords: Hysteroscopy, In vitro fertilization-embryo transfer (IVF-ET), Microcoil, Tubal hydrosalpinx, Tubal embolization
Received: 10 Apr 2025; Accepted: 06 Oct 2025.
Copyright: © 2025 Taotao, Cai, Cai, Liu, Yuan and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hualei Cai, 445857786@qq.com
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