ORIGINAL RESEARCH article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1609726
AIDET communication combined with alternating prone ventilation for HIF-1α, sTREM-1 and hs-CRP in awake elderly patients with severe pneumonia
Provisionally accepted
- Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, China
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Background: Severe pneumonia in elderly patients carries high mortality, with inflammatory markers such as HIF-1α, sTREM-1, and hs-CRP associated with disease severity. Combining alternating prone ventilation with AIDET communication may improve outcomes. Objective: To evaluate the effects of AIDET communication combined with alternating prone ventilation on comfort, oxygenation, inflammatory markers, and prognosis in awake elderly patients with severe pneumonia. Methods: A total of 86 elderly patients were enrolled and assigned to either an AIDET group or a Conventional group (n = 43 each). Comfort scores, PaO₂/FiO₂ ratios, and serum levels of HIF-1α, sTREM-1, and hs-CRP were assessed at baseline and 72 hours. Weaning success and time to withdrawal were also recorded. Results: At 72 hours, the AIDET group demonstrated significantly higher comfort scores (T12: 8.3 ± 0.9 vs. 6.5 ± 1.1; P < 0.001) and improved oxygenation (PaO₂/FiO₂: 289.4 ± 23.5 vs. 231.2 ± 20.6; P < 0.001). Reductions in inflammatory markers were greater in the AIDET group: HIF-1α (↓ 24.3%; P < 0.001), sTREM-1 (↓22.7%; P = 0.003), and hs-CRP (↓28.1%; P < 0.001). Weaning success was higher in the AIDET group (95.3% vs. 76.7%; P = 0.013) with a shorter median time to weaning (47h vs. 62h; P < 0.001). Conclusion: In elderly patients with severe pneumonia, AIDET communication combined with prone ventilation significantly improves comfort, oxygenation, and biomarker profiles, and enhances weaning success. These findings support the integration of structured communication into respiratory care protocols.
Keywords: AIDET communication, Alternating prone ventilation, Inflammatory markers, Patient outcomes, Severe pneumonia
Received: 10 Apr 2025; Accepted: 26 Aug 2025.
Copyright: © 2025 Wang, Zhang, Li and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: YanHong Wang, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, China
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