CASE REPORT article
Front. Med.
Sec. Dermatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1610203
Bleomycin-induced flagellate-like skin pigmentation in a 15-year-old girl: A case report and review
Provisionally accepted
- 1The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
- 2First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
- 3Department of Oncology, The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
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We present a detailed report of a case of flagellar-like skin pigmentation observed in a 15-year-old female patient diagnosed with ovarian yolk sac tumor following administration of a chemotherapy regimen containing bleomycin. After three cycles of chemotherapy, the patient exhibited characteristic painless, non-pruritic linear hyperpigmentation on her trunk and back. This case underscores the significance of paying attention to bleomycin-associated dermal toxicity, emphasizing the need for its early detection and management to alleviate the patient's psychological and physical distress. Our research indicates that additional studies are necessary to comprehensively understand the underlying mechanisms of flagellar-like skin pigmentation and to identify effective prevention and treatment approaches.
Keywords: Bleomycin, Flagellate hyperpigmentation, dermal toxicity, Ovarian yolk sac tumor, Adverse Reactions
Received: 14 Apr 2025; Accepted: 09 Jul 2025.
Copyright: © 2025 Chen, Chaungjie, Wang and Zhai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Linzhu Zhai, Department of Oncology, The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
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