ORIGINAL RESEARCH article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1610726
Association between Red Cell Distribution Width-to-Albumin Ratio and All-Cause Mortality in Critically Ill Cirrhotic Patients with Sepsis: A Retrospective Analysis of the MIMIC-IV Database
Provisionally accepted
- 1Wuming Hospital Affiliated to Guangxi Medical University, Nanning, Guangxi Zhuang Region, China
- 2Guangxi Zhuang Autonomous Region Ethnic Hospital, Nanning, China
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Background: Critically ill cirrhotic patients are at high risk of infections, which are associated with significantly increased mortality. The red cell distribution width-to-albumin ratio (RAR) is a validated predictor of mortality in critically ill patients. However, the prognostic value of RAR in critically ill cirrhotic patients with sepsis has not been fully established.This study retrospectively analyzed data from the MIMIC-IV database. Patients were stratified into quartiles based on RAR values. The primary outcomes were 30-day and 365-day all-cause mortality. Kaplan-Meier survival analysis and multivariable Cox regression models were applied to assess the association between RAR and mortality. Restricted cubic spline (RCS) analysis confirmed a linear relationship and subgroup analyses explored potential interactions.Results: A total of 2,100 patients were included. Elevated RAR values were significantly associated with increased 30-day and 365-day all-cause mortality. Compared with the lowest quartile, patients in the highest RAR quartile had a 51% higher risk of 30-day mortality (HR = 1.51, 95% CI:1.19-1.92) and a 51% higher risk of 365-day mortality (HR = 1.51, 95% CI: 1.25-1.81). RCS analysis confirmed a significant linear relationship between RAR and mortality risk. Subgroup analyses showed a stronger association between RAR and mortality in elderly patients.In critically ill cirrhotic patients with sepsis, elevated RAR values are independently associated with increased all-cause mortality risk. This study highlights the potential of RAR as a prognostic biomarker, particularly in elderly patients.
Keywords: cirrhosis, Sepsis, All-cause mortality, Red Cell Distribution Width-to-Albumin Ratio (RAR), prognosis
Received: 17 Apr 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Li, Pang, Huang, Lu, Tang, Wu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianlin Wu, Wuming Hospital Affiliated to Guangxi Medical University, Nanning, Guangxi Zhuang Region, China
Maowei Chen, Wuming Hospital Affiliated to Guangxi Medical University, Nanning, Guangxi Zhuang Region, China
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