The Relationship Between Peptic Ulcer and Cardiovascular Disease in Elderly Population: A Study on Mortality and Disease Development

Lin He¹Qianlei Wang²Yang Qiu¹Nan Shen¹Peimin Pu¹Ruiqing Wang¹Hongyu Miao¹Haiyan Zhang¹Xiao Yu¹Dinghong Xiao¹Lianjun Xing^1*Zhidong Liu^1*

• ¹Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
• ²Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality, China

Background: Peptic ulcer (PU) and cardiovascular disease (CVD) are significant chronic illnesses, particularly in the elderly. This study investigates the relationship between PU and CVD in older adults and the impact on mortality risk. Methods: This study was conducted utilizing data from a nationwide health survey of the elderly in China. Kaplan-Meier curves and log-rank tests were applied in survival analysis to evaluate mortality differences between the groups. Stratified models were applied to evaluate the effects of factors. Results: This study included 3636 participants. CVD was significantly associated with an increased PU risk (OR = 1.31, 95%CI 1.03-1.66, p = 0.04), while PU had no significant effect on CVD incidence (OR = 1.08, 95%CI 0.77-1.51, p = 0.64). Mortality risk was significantly higher in the CVD group (HR = 1.22, 95%CI 1.03-1.45, p = 0.02) compared to the non-comorbid group. No significant difference in mortality was observed between the PU-only and combined PU-CVD groups. Stratified analysis identified advanced age (≥75 years) (HR = 1.45, 95%CI 1.06-1.87, p < 0.01) and male gender (HR = 1.29, 95%CI 1.05-1.62, p < 0.01) as significant mortality risk factors among PU patients. Conclusion: PU does not have a significant impact on overall mortality or the prognosis of CVD patients. CVD was a risk factor for PU, but PU did not significantly increase CVD risk. A higher mortality risk was observed in older and male PU patients. These findings suggest the need for gender-sensitive and age-stratified management strategies for PU in high-risk groups.