SYSTEMATIC REVIEW article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1611304
Advancing lung organoids towards clinical applications: A global perspective on research focus and future directions
Provisionally accepted
- 1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 2Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
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Lung organoids have emerged as a promising tool for studying lung development, function, and disease pathology. The present study aimed to analyze the current status and development trends of lung organoid research over the past years, present visual representations, and provide references for future research directions using bibliometric analysis. Information on articles on lung organoids extracted from the Web of Science Core Collection, such as year of publication, journal, country, institution, author, and keywords, was analyzed. R, VOSviewer, and SCImago Graphica were used to visualize publication trends, co-authorship analysis, co-occurrence analysis, and hotspot evolution. The number of global publications has increased from 1 in 2011 to 929 in 2024. The Nature produced the highest number of citations (2675 citations). The United States (8155 citations and 281 publications), University Medical Center Utrecht (2083 citations and 11 publications), and Clevers H (2711 citations and 21 publications) were the most influential countries, institutions, and authors, respectively. Co-occurrence cluster analysis of the top 54 keywords formed four clusters: (1) idiopathic pulmonary fibrosis, (2) lung cancer, (3) cystic fibrosis, (4) COVID-19. Overall, research on lung organoids continues to increase. The United States of America and the Netherlands dominated global studies. The analysis of pulmonary fibrosis, lung cancer and COVID-19 occupied a prominent position of research in this area. The research hotspots for lung organoids are disease model and microphysiological systems. Standardization, accurate disease modeling, and ethics and safety remain pressing challenges that need to be addressed in this field.
Keywords: Lung organoids, clinical applications, Research focus, Future Directions, Bibliometric
Received: 14 Apr 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Wang, Tan, Fu, He, Ma, You, You and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Liting You, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China
Yi-Feng Ren, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
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