REVIEW article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1611640
Research Progress and Perspectives of Non-coding RNAs in Primary Biliary Cholangitis: From Mechanisms to Therapeutics
Provisionally accepted
- 1Department of Gastroenterology, First Affiliated Hospital, Nanjing Medical University, Nanjing, Liaoning Province, China
- 2Nanjing Medical University, Nanjing, China
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Primary biliary cholangitis (PBC), an autoimmune-mediated cholestatic liver disease with a female predominance, remains enigmatic in its pathogenesis despite advances in understanding immune dysregulation, bile acid homeostasis, inflammatory cascades, gut-liver axis crosstalk, and sex-biased mechanisms. Although ursodeoxycholic acid is widely recognized as the first-line therapy, its variable efficacy underscores the need for novel biomarkers and targeted therapies. Non-coding RNAs (ncRNAs), though not encoding proteins, have emerged as promising candidates due to their pivotal regulatory roles in autoimmune processes. This review systematically delineates the interplay between ncRNAs (miRNAs, lncRNAs, circRNAs) and key PBC mechanisms, evaluates their diagnostic and therapeutic potential, and proposes future research frameworks to bridge molecular insights with clinical translation.
Keywords: Primary biliary cholangitis, non-coding RNA, Immune dysregulation, biomarker, Therapeutic target
Received: 14 Apr 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Chen, Li, Xie and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hong Zhu, Department of Gastroenterology, First Affiliated Hospital, Nanjing Medical University, Nanjing, Liaoning Province, China
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