REVIEW article
Front. Med.
Sec. Translational Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1612281
This article is part of the Research TopicExploring Adverse Drug Reactions: Monitoring, Mechanism, Intervention, and ResolutionView all 8 articles
Application and research progress of tranexamic acid in the perioperative period of posterior lumbar interbody fusion
Provisionally accepted
- 1Chongqing Traditional Chinese Medicine Orthopedic Hospital, Chongqing, China
- 2Department of Orthopedics, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Posterior lumbar interbody fusion requires stripping the multifidus muscle, destroying a large amount of cancellous bone and damaging the posterior spinal venous plexus. Typically, surgical trauma is extensive, the surgical duration is long, and the degree of bleeding is substantial. Excessive blood loss can compromise a patient’s hemodynamic stability, elevate surgical risks, and cause damage to vital organs, potentially becoming life-threatening in severe cases. Tranexamic acid (TXA) is a lysine derivative that can inhibit fibrinolysis, reduce D-dimer production, and reduce inflammation. In this review, we discuss the application of and research progress on TXA regarding its mechanism of action, mode of administration, timing, dose, safety, and economic benefits. The primary purpose of this review is to provide an essential reference for the administration of TXA during posterior lumbar interbody fusion surgery as well as a reference for future research.
Keywords: Tranexamic Acid, Posterior lumbar interbody fusion, Mode of administration, Timing and dose of administration, Research progress
Received: 15 Apr 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Dong, Tang, Zhou, Li, Wu, Liu, Yan, Peng and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhenggang Peng, Chongqing Traditional Chinese Medicine Orthopedic Hospital, Chongqing, China
Jun Zhao, Chongqing Traditional Chinese Medicine Orthopedic Hospital, Chongqing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.