ORIGINAL RESEARCH article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1614342
This article is part of the Research Topic25 Years of 21st Century MedicineView all 7 articles
Identification and validation of mitochondria-related genes in panvascular diseases
Provisionally accepted
- Department of Gerontology, The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China
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Panvascular diseases represent a spectrum of vascular conditions where atherosclerosis plays a central role in the pathophysiology. This study focused on identifying differentially expressed genes (DEGs) related to mitochondria and key genes associated with peripheral artery disease (PAD) and coronary artery disease (CAD). This study identified MPV17 as a key mitochondrial gene bridging peripheral artery disease (PAD) and coronary artery disease (CAD). Analysis of GEO datasets revealed differentially expressed mitochondrial genes, with MPV17, FADD, HLCS, and PEX3 highlighted. A diagnostic nomogram, developed using LASSO and Random Forest methods, demonstrated high accuracy in predicting PAD and CAD (AUC >0.93). Furthermore, the study revealed significant alterations in immune cell infiltration associated with both diseases, suggesting a potential role for immune modulation in panvascular disease. MPV17 shows promise as a diagnostic marker for early identification and differentiation of these vascular conditions.
Keywords: Panvascular diseases, peripheral artery disease, Coronary Artery Disease, Mitochondria-related genes, Immune infiltration
Received: 18 Apr 2025; Accepted: 24 Jun 2025.
Copyright: © 2025 Li, Ma and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shenzhou Ma, Department of Gerontology, The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong Province, China
Guang Yang, Department of Gerontology, The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong Province, China
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