CASE REPORT article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1614699
Case Report: IVCM of Corneal Chlorpromazine Toxicity Drug Deposits
Provisionally accepted
- Eye Center, Xiamen University, Xiamen, China
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To investigate corneal deposits in a patient undergoing long-term chlorpromazine therapy using in vivo confocal microscopy with the HRT II Rostock Corneal Module. We reported A 45-year-old woman with a 7-year history of chlorpromazine therapy presented with bilateral photophobia and a 4-year history of gradual-onset blurred vision. Slit-lamp examination revealed yellowish deposits in the corneal endothelium and Descemet's membrane. In vivo confocal microscopy identified irregular hyper-reflective deposits in all corneal layers. The epithelial and superficial stromal deposits had well-defined edges, while the posterior stromal, Descemet's membrane, and endothelial deposits appeared as hollow granules and streaks. This study is the first to use in vivo confocal microscopy to identify crystalline deposits in the corneal stroma and endothelium caused by high-dose chlorpromazine. These findings offer new insights into drug metabolism on the ocular surface and provide a basis for future research.
Keywords: Chlorpromazine, Ocular surface, Toxicity, Corneal, Drug deposits, In vivo confocal microscopy
Received: 19 Apr 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Xianwen, Fang, Xie, Luo, Lin and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuan Lin, Eye Center, Xiamen University, Xiamen, China
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