CASE REPORT article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1614725
Congenital Candidemia due to Non-albicans Candida Species-A report of two cases and literature review
Provisionally accepted
- 1Pediatric Nephrology Clinic, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
- 2Dongguan Maternal and Child Health Care Hospital, Dongguan, China
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Congenital candidiasis caused by non-albicans Candida (NAC) species represents a life-threatening condition with significant underreporting in clinical literature. It mainly manifests as systemic invasive candidiasis. Premature infants are affected more easily due to the immaturity of their immune system. Risk factors such as those with IVF-associated, premature membrane rupture, and the presence of intrauterine devices are reported to be associated with CSC.We present two cases of extremely preterm neonates diagnosed with congenital systemic candidiasis(CSC): case 1 involved Candida tropicalis infection, while case 2 exhibited Candida glabrata infection. Based on the literature reports, we conduct a review on CSC due to NAC.We highlight the importance of early recognition and treatment in neonates born to mothers with risk factors.It is recommended that maternal screening for candidiasis and prophylactic antifungal treatment should be conducted promptly for mothers with risk factors when signs of preterm birth appear. CSC should be taken into consideration when unaccountable disseminated infections occur in preterm infants and antifungal therapy should be administered as soon as possible
Keywords: congenital systemic candidiasis, Candidemia, non-candida albicans infection, Intrauterine Infection, literature review
Received: 19 Apr 2025; Accepted: 12 Jun 2025.
Copyright: © 2025 Yu, Zhang, Wen, Zhong and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Minxu Li, Dongguan Maternal and Child Health Care Hospital, Dongguan, China
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