ORIGINAL RESEARCH article
Front. Med.
Sec. Rheumatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1615561
Frontal QRS-T Angle Remains Unchanged in Fibromyalgia: A Cross-Sectional Study with Implications for Routine ECG Screening
Provisionally accepted
- School of Medicine, Selcuk University, Konya, Türkiye
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Aim: Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread pain and associated with systemic diseases. Although autonomic dysfunction in FMS may predispose to cardiac arrhythmias, its impact on cardiac parameters, such as the frontal QRS-T (f(QRS-T)) angle, remains unclear. This study aimed to investigate the f(QRS-T) angle in FMS patients compared to healthy controls. Methods: A total of 75 FMS patients and 75 healthy controls were included in this crosssectional study. Disease severity was assessed using the Fibromyalgia Impact Questionnaire (FIQ). The f(QRS-T) angle was calculated from 12-lead electrocardiograms by a blinded cardiologist. Associations between the f(QRS-T) angle, FIQ scores, and duloxetine use were analyzed using appropriate statistical methods.Results: No significant differences in the f(QRS-T) angle were observed between FMS patients and controls (p=0.973). Additionally, no correlation was found between FIQ scores and the f(QRS-T) angle (p=0.725). Subgroup analysis revealed no significant differences in the f(QRS-T) angle between FMS patients using duloxetine and those not using it (p=0.503).Conclusion: Contrary to concerns about subclinical cardiac involvement in FMS, our findings reveal no significant alterations in the f(QRS-T) angle among FMS patients. Moreover, disease severity and duloxetine use do not influence this parameter. These results challenge the assumption of clinically relevant cardiac dysregulation in FMS and suggest that routine ECG screening may not be necessary for patients with FMS. Nonetheless, longitudinal studies are warranted to fully clarify the long-term cardiac risk in this population.
Keywords: Fibromyalgia, Frontal QRS-T angle, electrocardiogram, arrhythmia, Chronic Pain, autonomic dysfunction, duloxetine, Cardiac Screening
Received: 21 Apr 2025; Accepted: 19 Jun 2025.
Copyright: © 2025 Tezcan and AKYILDIZ TEZCAN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hüseyin Tezcan, School of Medicine, Selcuk University, Konya, Türkiye
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