BRIEF RESEARCH REPORT article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1615571
This article is part of the Research TopicAdvances in Vaginal Microbiome and Metabolite Research: Genetics, Evolution, and Clinical PerspectivesView all 15 articles
Cervical Microbiota Diversity and Functional Shifts in the Development of Cervical High-Grade Squamous Intraepithelial Lesions
Provisionally accepted
Marta Rosas Cancio-Suárez1,2*
Elena Moreno1,2
Cristina Del Valle Rubido1Marta Salvador1Ana Moreno3Laura Luna1
Claudio Díaz-García1,2Carlos Tapia1
Ana Del Amo1
Santiago Moreno1,2
MATILDE Sánchez-CONDE1,2
Sergio Serrano-Villar1,2- 1Ramón y Cajal University Hospital, Madrid, Spain
- 2Networked Biomedical Research Center for Infectious Diseases (CIBERINFEC), Madrid, Asturias, Spain
- 3Alpes Primary Care Center, Madrid, Spain
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Research on microbial changes in the cervix, where most human papillomavirus (HPV) complications arise, is limited. Here, we aimed to understand the specific role of the cervicovaginal microbiota in developing high-grade squamous intraepithelial lesions (HSIL) associated with HPV infection. Our results show higher diversity in the microbiota associated with HSIL, with the genera Parvimonas, Fastidiosipila, and Pseudomonas being the most abundant. Additionally, an imputed functional analysis revealed that pathways such as glycine, serine, threonine, and sulfur metabolism were enriched in cervical samples from women with HSIL. Identifying biomarkers that help prevent HSIL progression could benefit women at risk of developing HPV-related cancerous lesions.
Keywords: #HSIL, #cervicovaginal microbiota, #16s, #HPV, #bacterialfunctions
Received: 26 Apr 2025; Accepted: 08 Oct 2025.
Copyright: © 2025 Rosas Cancio-Suárez, Moreno, Del Valle Rubido, Salvador, Moreno, Luna, Díaz-García, Tapia, Del Amo, Moreno, Sánchez-CONDE and Serrano-Villar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Marta Rosas Cancio-Suárez, mrcancio.3@gmail.com
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