SYSTEMATIC REVIEW article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1615753
Research Trends and Topics on Sepsis Immunosuppression: A Bibliometric and Visual Analysis of Global Research From 2004 to 2024
Provisionally accepted
YONG JIANG1,2,3,4,5*
Ji Yin5
Yantong Wan5
Guangqin Chen5
Nanhong Li5
Fei Liu5Haihua Luo1,2,3,5Yijing Li5Shan Li4*- 1Institute of Infection and Immunity, Henan Academy of Innovations in Medical Science, zhengzhou, China
- 2Henan International Joint Laboratory of Infection and Immmunology, Department of Critical Care Medicine and Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, zhengzhou, China
- 3Department of Respiratory and Critical Care Medicine, Affiliated Dongguan Hospital, Southern Medical University, Guangdong, China, Dongguan, China
- 4Department of Anesthesiology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China
- 5Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
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Background Sepsis, a condition characterized by critical organ impairment resulting from dysregulated response to infection, remains a leading cause of mortality globally.Immunosuppression significantly dictates the clinical trajectory and ultimate prognosis in sepsis.Research on sepsis-related immunosuppression has gained substantial attention in recent years.However, a comprehensive and objective analysis of the current state of research remains scarce.This study employs bibliometric techniques and knowledge mapping to provide a visual analysis of trends and developments in sepsis immunosuppression, offering a systematic overview for researchers in the field.This study aims to: (1) Quantitatively characterize global publication trends, key contributors (countries/institutions/authors), and collaborative networks in sepsis immunosuppression research (2004-2024); (2) Identify current hotspots and future directions in this field. Materials and Methods Articles and reviews related to sepsis immunosuppression were sourced from the Web of Science Core Collection via subject-specific searches. Bibliometric analyses were executed using Excel 365, CiteSpace, VOSviewer, and Bibliometrix (R-Studio's R-Tool).
Keywords: Sepsis, Immunosuppression, bibliometric analysis, Immunoparalysis, Clinical treatment
Received: 21 Apr 2025; Accepted: 22 Jul 2025.
Copyright: © 2025 JIANG, Yin, Wan, Chen, Li, Liu, Luo, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
YONG JIANG, Institute of Infection and Immunity, Henan Academy of Innovations in Medical Science, zhengzhou, China
Shan Li, Department of Anesthesiology, Third Affiliated Hospital, Southern Medical University, Guangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.