ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1618436
The Change of Retinal Microvascular in APAC Eyes and Fellow PACS Eyes Detected Using Wide-Field Swept-Source Optical Coherence Tomographic Angiography
Provisionally accepted
- 1Shandong Lunan Eye Hospital, Linyi, Shandong Province, China
- 2Shandong Provincial Hospital, Jinan, Shandong Province, China
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This study aimed to quantitatively evaluate changes in vascular parameters in a 12mm×12mm region centered on the fovea with wide-field swept-source optical coherence tomographic angiography (WF SS-OCTA), and establish their correlations with structural parameters in acute primary angle closure (APAC) eyes, as well as in fellow primary angle-closure suspect (PACS) eyes.In this retrospective study, WF SS-OCTA was utilized to measure vascular parameters in a 12mm×12mm region centered on the fovea in 31 patients (31 APAC eyes and 31 fellow PACS eyes).Vascular parameters included vessel density (VD) of the superficial vascular complex (SVC) and deep vascular complex (DVC). Structural parameters comprised macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber layer (pRNFL) thickness. Pre-and postoperative(3 month after APAC attack) differences between APAC and PACS eyes were statistically analyzed.Results: No significant differences were observed in vascular density or structural parameters in PACS eyes pre-and postoperatively (P>0.05). In APAC eyes, postoperative SVC VD showed no significant change in the 0-6 mm region but decreased significantly in the 6-12 mm annular region centered on the fovea (P<0.05). DVC VD increased across all scanned regions postoperatively (P<0.05). The average pRNFL thickness, quadrant-specific pRNFL thickness, and GCC thickness were significantly reduced after operation(P<0.05). Multivariate linear regression revealed positive correlations between GCC thickness, SVC VD (0-6 mm, 0-12 mm, 6-12 mm), and pRNFL thickness (P<0.001).Conclusions: Wide-field SS-OCTA revealed spatially distinct vascular responses in APAC eyes: underlying axonal loss with concomitant SVC compromise in the 6-12 mm annular region centered on the fovea and partial DVC recovery at 3 months after APAC attack, highlighting WF SS-OCTA's utility in monitoring APAC progression.
Keywords: acute primary angle closure, Primary angle-closure suspect, wide-field OCTA, Superficial vascular complex, retinal nerve fiber layer
Received: 26 Apr 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Zhao, Geng, Zhang, Wu, Wang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bojun Zhao, Shandong Provincial Hospital, Jinan, 250021, Shandong Province, China
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