ORIGINAL RESEARCH article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1618631
Antibiotic Prophylaxis may be still required among Transperineal Prostate Biopsies of Diabetics: A Cohort Study
Provisionally accepted
Feiyue Ma*
Yu Zhang- No.1 People's Hospital of Xiangshan, Ningbo, China
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Background: Transperineal prostate biopsy (TP-PB) is considered the gold standard for suspected prostate cancer patients. However, the rate of transperineal prostate biopsy-related urinary tract infections (UTIs) has been calculated to be as high as 3%. This study aimed to discuss the incidence of transperineal prostate biopsy -related infections among diabetic patients who underwent antibiotic prophylaxis (AP) or not.Methods: The monocentric, comparative, observational cohort study was carried out at Xiangshan County First People's Hospital Medical Health Group, China between January 2021 and January 2023. The study included 246 diabetic men suspected of having prostate cancer who underwent transperineal prostate biopsy. One group was transperineal prostate biopsy with no antibiotic prophylaxis (Group A-no AP, n=120, 48.8%), and the other was given a 3-day of oral antibiotics (Group B-AP, n=126, 51.2%). Data on primary symptoms, urine culture (UC), urinary tract infections incidence, and prostate biopsy -related sequelae were gathered two weeks following the prostate biopsy.Results: A total of 246 patients were involved, including 120 in Group A (67.4 ± 7.2 years) and 126 in Group B (68.5 ± 7.0 years) (p = 0.215). Prostate-specific antigen (PSA) levels were 16.1 ± 23.8 vs. 15.9 ± 22.3 ng/ml (p=0.942), and the prostate cancer detection rate was 58% vs. 57.5% (p=0.847). The incidence of asymptomatic bacteriuria was significantly higher (8/120, 6.7%) in Group A vs. Group B (1/126, 0.8%) (RR 8.4, 95% CI: 1.1-72.5, p<0.001). Similarly, urinary irritation symptoms occurred in 30/120 (25.0%) vs. 5/126 (4.0%) patients (RR 6.3, 95% CI: 3.0-21.6, p<0.001), fever in 9/120 (7.5%) vs. 1/126 (0.8%) (RR 9.5, 95% CI: 1.3-81.3, p=0.001), and UTIs in 5/120 (4.2%) vs. 1/126 (0.8%) (RR 5.3, 95% CI: 0.63-47.2, p=0.001), respectively. Notably, sepsis was not detected in either group.Conclusions: Antibiotic prophylaxis could decrease the incidence of transperineal prostate biopsy-related infections among diabetic patients.
Keywords: The monocentric, comparative, observational cohort study was carried out Transperineal prostate biopsy, prostate cancer, Urinary Tract Infections, Diabetic patients, Antibiotic Prophylaxis
Received: 26 Apr 2025; Accepted: 19 Jun 2025.
Copyright: © 2025 Ma and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Feiyue Ma, No.1 People's Hospital of Xiangshan, Ningbo, China
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