ORIGINAL RESEARCH article
Front. Med.
Sec. Hepatobiliary Diseases
This article is part of the Research TopicImmunological Aspects of Fibrosis Pathogenesis: Novel Mechanisms and Therapeutic StrategiesView all 31 articles
The Association Between Intrahepatic Malignant Tumors and Hepatitis B-Related Pathological Cirrhosis:A Retrospective Cohort Study
Provisionally accepted
- 1Fudan University, Shanghai, China
- 2Shanghai Public Health Clinical Center, Fudan University, Shanghai, Shanghai Municipality, China
- 3Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, Shanghai Municipality, China
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Hepatocellular carcinoma (HCC) is one of the most common and aggressive malignancies worldwide, with chronic hepatitis B virus (HBV) infection being the primary etiology. HBV-induced liver fibrosis and cirrhosis are significant pathological foundations for the development of HCC. Although several predictive models for HCC in patients with chronic hepatitis B (CHB) exist, a unified model for predicting the progression from cirrhosis, based on pathological diagnosis, to HCC has not yet been established. This study aims to explore the probability and predictive factors of intrahepatic malignant tumor development from a pathological perspective, providing a theoretical basis for clinical intervention.
Keywords: Hepatocellular Carcinoma, Hepatitis B virus, HBV, liver fibrosis, cirrhosis, intrahepatic malignant tumor, predictive model, Predictive factors
Received: 26 Apr 2025; Accepted: 24 Oct 2025.
Copyright: © 2025 Li, Liu, Lin, Huang, Zhang and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhanqing Zhang, zhangzhanqing@shaphc.org
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