MINI REVIEW article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1619087
This article is part of the Research TopicAcute Pancreatitis Infection: Epidemiology, Prevention, Clinical Characteristics, Treatment, and Prediction: Volume IIView all 3 articles
Biomarkers to predict the severity of acute pancreatitis
Provisionally accepted
- Department of Gastroenterology, the First Medical Center of Chinese PLA General Hospital, Beijing, China
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Acute pancreatitis (AP) is pancreatic inflammation caused by abnormal activation of trypsinogen, and moderately severe or severe acute pancreatitis can lead to systemic inflammatory response syndrome (SIRS) and organ failure, associated with high mortality. Therefore, early prediction of the severity of acute pancreatitis is particularly important to improve patient survival rate and reduce complications. Currently, many scoring systems (e.g. Ranson scoring, etc) and classical biomarkers are available in the clinical practice, but there are still many limitations, such as low predictive value and time delay. Potential biomarkers for the prediction of SAP are still a hot topic in current research. In this review, we aim to summarize newly discovered biomarkers for the prediction of the severity of acute pancreatitis in the recent years, and provide an overview of serum markers, intestinal flora, and genetic markers. At the same time, the development of emerging detection technologies (e.g.RAPIDx and ddPCR) also provides new possibilities for early prediction of SAP, allowing these biomarkers to be applied clinically.
Keywords: acute pancreatitis, biomarkers, extracellular traps, intestinal flora, mitochondrial DNA
Received: 27 Apr 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 XinWei, Bi, Wang, Niu, Li and Chai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ningli Chai, Department of Gastroenterology, the First Medical Center of Chinese PLA General Hospital, Beijing, China
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