ORIGINAL RESEARCH article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1619929
Liver cirrhosis may increase the incidence of delayed bleeding and mortality after endoscopic retrograde cholangiopancreatography for common bile duct stones.
Provisionally accepted
- 1First Affiliated Hospital of Wannan Medical College, Wuhu, China
- 2Affiliated Hospital of Xuzhou Medical University, xuzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background and purpose: Choledocholithiasis is a common disease. However, the results of studies on the complications of choledocholithiasis with cirrhosis by endoscopic retrograde cholangiopancreatography (ERCP) are inconsistent. Therefore, the purpose of this prospective study is to compare the incidence of postoperative complications of ERCP between choledocholithiasis with cirrhosis and those without cirrhosis. Patients and Methods: A total of 259 choledocholithiasis patients were include in this study. According to whether the choledocholithiasis patients were complicated with cirrhosis, they were divided into cirrhosis group and non-cirrhosis group. The incidence of post-ERCP pancreatitis (PEP), delayed bleeding, infection, perforation, and mortality were compared between the two groups. Results: There were 34 choledocholithiasis patients with cirrhosis and 225 patients without cirrhosis. There were statistically significant differences in delayed hemorrhage (P=0.046) and mortality (P=0.017) between the two groups. The rate of delayed hemorrhage and mortality in choledocholithiasis with cirrhosis patients group were significantly higher than those without cirrhosis. There were no statistically significant differences in PEP (P=0.917), postoperative biliary tract infection (P=0.130), stone clearance (P=0.201), and perforation (P=1.000) between the two groups. Conclusions: The results of this study found that cirrhosis may be associated with the occurrence of ERCP complications. Delayed hemorrhage and mortality after ERCP in choledocholithiasis patients with cirrhosis were significantly higher than those without cirrhosis.
Keywords: Choledocholithiasis, cirrhosis, ERCP, Delayed hemorrhage, Mortality
Received: 29 Apr 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Li, Wang and Niu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoping Niu, First Affiliated Hospital of Wannan Medical College, Wuhu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.